On December 15, 2006, Bill Rancic and Giuliana announced their engagement. The two were married on September 1, 2007 in a ceremony on Capri at Santa Sophia Church in Anacapri.
Giuliana Rancic appeared on The View with husband Bill to discuss her fertility issues. The couple have been trying to conceive since approximately the beginning of 2009. Her doctors had recommended that she gain weight in order to increase the chances of pregnancy. In February 2010, she stated that she had gained five pounds, and was working on gaining more weight. The couple began in vitro fertilization (IVF) in March 2010, and got pregnant in the spring of 2010, however Giuliana suffered a miscarriage at eight weeks. Rancic had an IVF transfer for a second time in November 2010, however the procedure did not result in a pregnancy. On October 17th 2011 during an interview on The Today Show, Giuliana announced that she was in the early stages of breast cancer.